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AIDS Can Be Ended by 2030 With Investments in Prevention and Treatment, UN Says

It is possible to end AIDS by 2030 if countries demonstrate the political will to invest in prevention and treatment and adopt non-discriminatory laws, the United Nations said on Thursday. In 2022, an estimated 39 million people around the world were living with HIV, according to UNAIDS, the United Nations AIDS program. HIV can progress to AIDS if left untreated. "We have a solution if we follow the leadership of countries that have forged strong political commitment to put people first and invest in evidence-based HIV prevention and treatment programmes," UNAIDS said in a report published on Thursday. It said an effective response to HIV also meant adopting non-discriminatory laws and empowering community networks, among other initiatives. People living with HIV or AIDS in many countries face stigma, discrimination and violence. "Progress has been strongest in the countries and regions that have the most financial investments, such as in eastern and southern Africa, where new HIV infections have been reduced by 57% since 2010," the report said. It added, however, that there has been a steep increase in new infections in eastern Europe and central Asia, as well as in the Middle East and North Africa. "These trends are due primarily to a lack of HIV prevention services for marginalized and key populations and the barriers posed by punitive laws and social discrimination," it said. Last year, 1.3 million people became newly infected with HIV and 630,000 died from AIDS-related illnesses, according to UNAIDS.

  • 27 July, 14:58
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Investigating Associations of Omega-3 Fatty Acids, Lung Function Decline, and Airway Obstruction

Rationale: Inflammation contributes to lung function decline and the development of chronic obstructive pulmonary disease. Omega-3 fatty acids have anti-inflammatory properties and may benefit lung health. Objectives: Investigate associations of omega-3 fatty acids with lung function decline and incident airway obstruction in diverse adults from general population cohorts. Methods: Complementary study designs: (1) longitudinal study of plasma phospholipid omega-3 fatty acids and repeated FEV1 and FVC measures in the National Heart, Lung, and Blood Institute Pooled Cohorts Study, and (2) two-sample Mendelian Randomization (MR) study of genetically predicted omega-3 fatty acids and lung function parameters. Measurements and Main Results: The longitudinal study found that higher omega-3 fatty acid levels were associated with attenuated lung function decline in 15,063 participants, with the largest effect sizes for the most metabolically downstream omega-3 fatty acid, docosahexaenoic acid (DHA). An increase in DHA of 1% of total fatty acids was associated with an attenuation of 1.4 mL/year for FEV1 (95% confidence interval [CI] 1.1–1.8) and 2.0 mL/year for FVC (95% CI 1.6–2.4) and a 7% lower incidence of spirometry-defined airway obstruction (95% CI 0.89–0.97). DHA associations persisted across sexes, smoking histories, and Black, white and Hispanic participants, with the largest magnitude associations in former smokers and Hispanics. The MR study showed similar trends towards positive associations of genetically predicted downstream omega-3 fatty acids with FEV1 and FVC. Conclusions: The longitudinal and MR studies provide evidence supporting beneficial effects of higher levels of downstream omega-3 fatty acids, especially DHA, on lung health.

  • 24 July, 17:47
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